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Article

The effect of amino groups on the stability of DNA duplexes and triplexes based on purines derived from inosine.

Nucleic acids research - 15 Jun 2001

Cubero E, Güimil-García R, Luque F J, Eritja R, Orozco M

Abstract excerpt

The effect of amino groups attached at positions 2 and 8 of the hypoxanthine moiety in the structure, reactivity and stability of DNA duplexes and triplexes is studied by means of quantum mechanical calculations, as well as extended molecular dynamics (MD) and thermodynamic integration (MD/TI) simulations. Theoretical estimates of the change in stability related to 2'-deoxyguanosine (G) --> 2'-deoxyinosine (I)...

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Identifiers

PMID: 11410660
DOI: 10.1093/nar/29.12.2522
PMCID: PMC55742

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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