Article

Regulation of RNA polymerase III transcription by the tumour suppressor p53

2002-01-01

Abstract excerpt

The tumour suppressor protein p53 is inactivated in a large proportion of human cancers. p53 controls growth and proliferation, through multiple mechanisms, including the ability to regulate transcription. p53 can function as a general repressor of RNA polymerase (pol) III transcription. Pol III is responsible for transcribing a variety of small stable RNAs including tRNA, 5S rRNA, and the adenoviral VA1 RNA. p53...

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Literature Corpus work: 5c7c8fc3-b7ea-5f58-91de-4f1841e7a300
DOI: 10.5525/gla.thesis.71244

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