Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p53 regulates a G <sub>2</sub> checkpoint through cyclin B1

2 Mar 1999

Abstract excerpt

The p53 tumor suppressor controls multiple cell cycle checkpoints regulating the mammalian response to DNA damage. To identify the mechanism by which p53 regulates G2, we have derived a human ovarian cell that undergoes p53-dependent G2 arrest at 32 degrees C. We have found that p53 prevents G2/M transition by decreasing intracellular levels of cyclin B1 protein and attenuating the activity of the cyclin B1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cancer Research and Treatments
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10051609
DOI: 10.1073/pnas.96.5.2147

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p53 regulates a G <sub>2</sub> checkpoint through cyclin B1PMID 10051609Read ↗

Analyzing the G2/M checkpoint.Semantic proximity Read ↗

Genomic instability and the role of p53 mutations in cancer cells.Semantic proximity Read ↗

The role of p53 mutation in BRCA1-associated ovarian cancer.Semantic proximity Read ↗

Cell cycle checkpoint control: The cyclin G1/Mdm2/p53 axis emerges as a strategic target for broad‑spectrum cancer gene therapy - A review of molecular mechanisms for oncologistsSemantic proximity Read ↗

Tumor-suppressor p53 and the cell cycle.Semantic proximity Read ↗

The G2 DNA damage checkpoint: Could this ancient regulator be the Achilles heel of cancer?Semantic proximity Read ↗

Tumour suppressors, kinases and clamps: How p53 regulates the cell cycle in response to DNA damageSemantic proximity Read ↗

Therapeutic Exploitation of Checkpoint Defects in Cancer Cells Lacking p53 FunctionSemantic proximity Read ↗

p53 is a NF-Y- and p21-independent, Sp1-dependent repressor of cyclin B1 transcription.Semantic proximity Read ↗

Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cells.Semantic proximity Read ↗

Cell cycle checkpoints, genetic instability and cancer.Semantic proximity Read ↗

Cell cycle checkpoints and their impact on anticancer therapeutic strategiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.