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Article

p53 Regulates the Minimal Promoter of the Human Topoisomerase II Gene

1 Nov 1996

Abstract excerpt

DNA topoisomerase IIalpha is an essential enzyme for chromosome segregation during mitosis. Consistent with a cell division-specific role, the expression of the topoisomerase IIalpha gene is strongly influenced by the proliferation status of cells. The p53 protein is one of the most important regulators of cell cycle progression in mammals, with an apparent dual role in the induction of cell cycle arrest...

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Identifiers

PMID: 8948636
DOI: 10.1093/nar/24.22.4464

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Research trail→

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p53 Regulates the Minimal Promoter of the Human Topoisomerase II GenePMID 8948636Read ↗

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Repression of RNA Polymerase I Transcription by the Tumor Suppressor p53Semantic proximity Read ↗

Influence of p53 tumor suppressor protein on bias of DNA repair and apoptotic response in human cells.Semantic proximity Read ↗

Identification of Promoter Elements Responsible for Transcriptional Inhibition of Polo-like Kinase 1 and Topoisomerase IIα Genes by p21WAF1/CIP1/ SDI1Semantic proximity Read ↗

p53-dependent repression of the human MCL-1 gene encoding an anti-apoptotic member of the BCL-2 family: the role of Sp1 and of basic transcription factor binding sites in the MCL-1 promoter.Semantic proximity Read ↗

The tumour suppressor protein p53 can repress transcription of cyclin B.Semantic proximity Read ↗

Wild-type but not mutant p53 can repress transcription initiation in vitro by interfering with the binding of basal transcription factors to the TATA motif.Semantic proximity Read ↗

Differential effect of p53 on the promoters of mouse DNA polymerase beta gene and proliferating-cell-nuclear-antigen gene.Semantic proximity Read ↗

Modulation of cellular and viral promoters by mutant human p53 proteins found in tumor cells.Semantic proximity Read ↗

Characterization of promoter elements involved in the down-regulation of topoisomerase IIalpha expression in a drug-resistant cell line.Semantic proximity Read ↗

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