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Article

Hepatitis C virus core protein represses the p21 promoter through inhibition of a TGF-beta pathway.

The Journal of general virology - 1 Sept 2002

Lee Mi Nam, Jung Eun Young, Kwun Hyun Jin, Jun Hong Ki, Yu Dae-Yeul, Choi Yung Hyun, Jang Kyung Lib

Abstract excerpt

The increased proliferation rate of hepatocytes is one of the major risk factors for the development of hepatocellular carcinoma. In this study, we investigated the mechanism by which hepatitis C virus (HCV) core protein represses transcription of the universal cyclin-dependent kinase inhibitor p21 gene in murine fibroblast NIH 3T3 cells. From the transient reporter assays of p21 promoter, we found that the...

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PMID: 12185267
DOI: 10.1099/0022-1317-83-9-2145

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Hepatitis C virus core protein represses the p21 promoter through inhibition of a TGF-beta pathway.PMID 12185267Read ↗

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