Article
The PPARgamma2 polymorphism pro12Ala is associated with better insulin sensitivity in the offspring of type 2 diabetic patients.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme - 1 Oct 2000
Jacob S, Stumvoll M, Becker R, Koch M, Nielsen M, Löblein K, Maerker E, Volk A, Renn W, Balletshofer B, Machicao F, Rett K, Häring H U
Abstract excerpt
Recently, a highly prevalent polymorphism of the PPARgamma2-receptor (Pro12Ala) was described and found to be associated with reduced transcriptional activity. Both human and animal studies suggested that this polymorphism may be associated with increased insulin sensitivity. However, an effect independent of other factors known to influence insulin sensitivity has yet to be demonstrated. Therefore, we compared...
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