Article
The PPARgamma2 amino acid polymorphism Pro 12 Ala is prevalent in offspring of Type II diabetic patients and is associated to increased insulin sensitivity in a subgroup of obese subjects.
Diabetologia - 1 Jun 1999
Koch M, Rett K, Maerker E, Volk A, Haist K, Deninger M, Renn W, Häring H U
Abstract excerpt
AIMS/HYPOTHESIS: Recently a mutation in the coding sequence of the adipocyte specific isoform peroxisome proliferator-activated receptor gamma2 (PPARgamma2) was described, leading to the substitution of Proline to Alanine at codon 12. Mutations in PPARgamma2 could have a role in people who are at increased risk for the development of obesity and Type II (non-insulin-dependent) diabetes mellitus. METHODS:...
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