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Article

Increased insulin clearance in peroxisome proliferator-activated receptor gamma2 Pro12Ala.

Metabolism: clinical and experimental - 1 Jun 2003

Tschritter Otto, Fritsche Andreas, Stefan Norbert, Haap Michael, Thamer Claus, Bachmann Oliver, Dahl Dominik, Maerker Elke, Teigeler Anna, Machicao Fausto, Häring Hans, Stumvoll Michael

Abstract excerpt

The Pro12Ala polymorphism of the peroxisome proliferator-activated receptor (PPARgamma(2)) is associated with reduced risk for type 2 diabetes. Although increased insulin sensitivity of glucose disposal and lipolysis has been reported, the exact mechanism by which the risk reduction is conferred is not clear. Because the conclusion of greater insulin sensitivity hinged upon lower insulin levels in some studies,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12800106
DOI: 10.1016/s0026-0495(03)00071-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Increased insulin clearance in peroxisome proliferator-activated receptor gamma2 Pro12Ala.PMID 12800106Read ↗

The PPARgamma2 polymorphism pro12Ala is associated with better insulin sensitivity in the offspring of type 2 diabetic patients.Semantic proximity Read ↗

Role of peroxisome proliferator-activated receptor gamma Pro12Ala polymorphism in human adipose tissue: assessment of adipogenesis and adipocyte glucose and lipid turnover.Semantic proximity Read ↗

Pro12Ala polymorphism of the PPARgamma2 locus modulates the relationship between energy intake and body weight in type 2 diabetic patients.Semantic proximity Read ↗

[Polymorphism of pro12Ala in peroxisome proliferator activated receptor gamma 2 (PPAgamma2): beta cell function and insulin sensitivity].Semantic proximity Read ↗

The proline 12 alanine substitution in the peroxisome proliferator--activated receptor-gamma2 gene is associated with lower lipoprotein lipase activity in vivo.Semantic proximity Read ↗

PPARgamma2 pro12Ala polymorphism and insulin resistance in Japanese hypertensive patients.Semantic proximity Read ↗

PPARgamma2 Pro12Ala polymorphism in relation to free fatty acids concentration and composition in lean healthy Czech individuals with and without family history of diabetes type 2.Semantic proximity Read ↗

The minor allele of the PPARgamma2 pro12Ala polymorphism is associated with lower postprandial TAG and insulin levels in non-obese healthy men.Semantic proximity Read ↗

The peroxisome proliferator-activated receptor-gamma2 gene polymorphism (Pro12Ala) beneficially influences insulin resistance and its tracking from childhood to adulthood: the Bogalusa Heart Study.Semantic proximity Read ↗

PPARGC1A coding variation may initiate impaired NEFA clearance during glucose challenge.Semantic proximity Read ↗

Association of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma2 with decreased basic metabolic rate in women with polycystic ovary syndrome.Semantic proximity Read ↗

Endurance training-induced changes in the insulin response to oral glucose are associated with the peroxisome proliferator-activated receptor-gamma2 Pro12Ala genotype in men but not in women.Semantic proximity Read ↗

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