Article
PPAR-gamma2 Pro12Ala variant is associated with greater insulin sensitivity in childhood obesity.
Pediatric research - 1 Jan 2005
Buzzetti Raffaella, Petrone Antonio, Caiazzo Assunta M, Alemanno Irene, Zavarella Sara, Capizzi Marco, Mein Charles A, Osborn John A, Vania Andrea, di Mario Umberto
Abstract excerpt
Several genetic variants of peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2), a molecule known to be involved in transcription of target genes, have been identified. Pro12Ala, a missense mutation in exon 2 of the gene, is highly prevalent in Caucasian populations. Conflicting conclusions about the association between this mutation and complex traits such as obesity, insulin sensitivity, and T2DM...
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