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Article

The PPARgamma Pro12Ala variant is associated with insulin sensitivity in Russian normoglycaemic and type 2 diabetic subjects.

Diabetes & vascular disease research - 1 Jan 2010

Chistiakov Dimitry A, Potapov Viktor A, Khodirev Dmitry S, Shamkhalova Minara S, Shestakova Marina V, Nosikov Valery V

Abstract excerpt

The second isoform of the PPARgamma2 is specific for adipose tissue. In adipocytes, this isoform is involved in the regulation of adipogenesis and lipid storage, insulin and glucose metabolism. Pro12Ala, a missense mutation in exon 2 of PPARG, reduces transcriptional activity of PPARgamma2 and is...

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Source

Identifiers

PMID: 20368233
DOI: 10.1177/1479164109347689

Genes

PPARG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20368233-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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The PPARgamma Pro12Ala variant is associated with insulin sensitivity in Russian normoglycaemic and type 2 diabetic subjects.PMID 20368233Read ↗

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