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Article

PPAR<i>γ</i>2<sup>Pro12Ala</sup> Polymorphism and Human Health

1 Jan 2009

Abstract excerpt

The nuclear hormone receptor peroxisome proliferator activated receptor gamma (PPARγ) is an important transcription factor regulating adipocyte differentiation, lipid and glucose homeostasis, and insulin sensitivity. Numerous genetic mutations of PPARγ have been identified and these mutations positively or negatively regulate insulin sensitivity. Among these, a relatively common polymorphism of PPARγ, Pro12Ala of...

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PMID: 19390629
DOI: 10.1155/2009/849538

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