The peroxisome proliferator-activated receptor-gamma2 Pro12A1a variant: association with type 2 diabetes and trait differences.

doi:10.2337/diabetes.50.4.886

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Article

The peroxisome proliferator-activated receptor-gamma2 Pro12A1a variant: association with type 2 diabetes and trait differences.

Diabetes - 1 Apr 2001

Douglas J A, Erdos M R, Watanabe R M, Braun A, Johnston C L, Oeth P, Mohlke K L, Valle T T, Ehnholm C, Buchanan T A, Bergman R N, Collins F S, Boehnke M, Tuomilehto J

Abstract excerpt

Recent studies have identified a common proline-to-alanine substitution (Pro12Ala) in the peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2), a nuclear receptor that regulates adipocyte differentiation and possibly insulin sensitivity. The Pro12Ala variant has been associated in some...

Topics

Aged
Blood Pressure
Diabetes Mellitus
Diabetes Mellitus, Type 2
Fasting
Female
Gene Frequency
Genetic Variation
Humans
Insulin
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Obesity

Receptors, Cytoplasmic and Nuclear

Reference Values

Transcription Factors

Triglycerides

Weight Gain

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Open in PubMed

Identifiers

PMID: 11289057
DOI: 10.2337/diabetes.50.4.886

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-11289057-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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The peroxisome proliferator-activated receptor-gamma2 Pro12A1a variant: association with type 2 diabetes and trait differences.PMID 11289057Read ↗

The association between the peroxisome proliferator-activated receptor-gamma2 (PPARG2) Pro12Ala gene variant and type 2 diabetes mellitus: a HuGE review and meta-analysis.Semantic proximity Read ↗

Peroxisome proliferator-activated receptor gamma 2 Pro12Ala gene variant is strongly associated with larger body mass in the Taiwanese.Semantic proximity Read ↗

The Peroxisome Proliferator-Activated Receptor-γ2 Pro12Ala PolymorphismSemantic proximity Read ↗

The PPARgamma Pro12Ala variant is associated with insulin sensitivity in Russian normoglycaemic and type 2 diabetic subjects.Semantic proximity Read ↗

The Pro12 -->Ala substitution in PPAR-gamma is associated with resistance to development of diabetes in the general population: possible involvement in impairment of insulin secretion in individuals with type 2 diabetes.Semantic proximity Read ↗

Pro12Ala of the peroxisome proliferator-activated receptor-gamma2 gene is associated with lower serum insulin levels in nonobese African Americans: the Atherosclerosis Risk in Communities Study.Semantic proximity Read ↗

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