Article
Comment: studies of the Pro12Ala polymorphism of the PPAR-gamma gene in the Danish MONICA cohort: homozygosity of the Ala allele confers a decreased risk of the insulin resistance syndrome.
The Journal of clinical endocrinology and metabolism - 1 Aug 2002
Frederiksen Laura, Brødbaek Kasper, Fenger Mogens, Jørgensen Torben, Borch-Johnsen Knut, Madsbad Sten, Urhammer Søren A
Abstract excerpt
The Pro12Ala polymorphism of PPAR-gamma 2 has been shown to influence insulin sensitivity and the risk of type 2 diabetes in various ethnic populations. We examined whether the polymorphism was related to the insulin resistance syndrome (IRS) among nondiabetic Danish subjects. The Pro12Ala variant was examined using PCR-restriction fragment length polymorphism in a phenotypically well characterized...
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