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Article

The common PPAR-gamma2 Pro12Ala variant is associated with greater insulin sensitivity.

European journal of human genetics : EJHG - 1 Dec 2004

Buzzetti Raffaella, Petrone Antonio, Ribaudo Maria Cristina, Alemanno Irene, Zavarella Sara, Mein Charles A, Maiani Francesca, Tiberti Claudio, Baroni Marco Giorgio, Vecci Elio, Arca Marcello, Leonetti Frida, Di Mario Umberto

Abstract excerpt

Several genetic variants of peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) have been identified, among which Pro12Ala, a missense mutation in exon 2, is highly prevalent in Caucasian populations. Up to now, conflicting results with regard to the association between this mutation and complex traits, such as obesity, insulin sensitivity and Type 2 diabetes, have been reported. We investigated the...

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PMID: 15367918
DOI: 10.1038/sj.ejhg.5201283

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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