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Article

Smoothing of the bivariate LOD score for non-normal quantitative traits.

BMC genetics - 30 Dec 2005

Buil Alfonso, Dyer Thomas D, Almasy Laura, Blangero John

Abstract excerpt

Variance component analysis provides an efficient method for performing linkage analysis for quantitative traits. However, type I error of variance components-based likelihood ratio testing may be affected when phenotypic data are non-normally distributed (especially with high values of kurtosis). This results in inflated LOD scores when the normality assumption does not hold. Even though different solutions have...

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Identifiers

PMID: 16451568
DOI: 10.1186/1471-2156-6-S1-S111
PMCID: PMC1866827

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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