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Article

Power of variance component linkage analysis to detect epistasis.

Genetic epidemiology - 1 Jan 1997

Mitchell B D, Ghosh S, Schneider J L, Birznieks G, Blangero J

Abstract excerpt

Variance component methods are now being used in linkage analysis to detect genes influencing complex diseases. These methods are easily extended to allow for simultaneous estimation of both the additive effects of multiple loci on phenotypic variation (conditional oligogenic analysis) and the additive interaction (epistatic) effects among loci. We performed linkage analyses on 200 of the simulated replicates in...

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Identifiers

PMID: 9433617
DOI: 10.1002/(SICI)1098-2272(1997)14:6<1017::AID-GEPI76>3.0.CO;2-L

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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