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Article

Beta2-microglobulin gene mutation is not a common mechanism of HLA class I total loss in human tumors.

International journal of clinical & laboratory research - 1 Jan 2000

Fernández M A, Ruiz-Cabello F, Oliva M R, Cabrera T, Jimenez P, López Nevot M A, Garrido F

Abstract excerpt

One hundred and sixty-two tumor samples were analyzed for HLA class I expression using immunohistological techniques. HLA class I total loss (phenotype no. I) was detected in 31 cases (19%), comprising 20 colorectal, 3 laryngeal, and 2 bladder carcinomas and 6 melanomas. Twenty-one cases were selected for molecular analysis due to a higher proportion of tumor cells versus stroma cells (75%). We investigated...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11043502
DOI: 10.1007/BF02874164

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Beta2-microglobulin gene mutation is not a common mechanism of HLA class I total loss in human tumors.PMID 11043502Read ↗

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