Article
A new beta 2 microglobulin mutation found in a melanoma tumor cell line.
Tissue antigens - 1 Jun 1999
Pérez B, Benitez R, Fernández M A, Oliva M R, Soto J L, Serrano S, López Nevot M A, Garrido F
Abstract excerpt
Beta2 microglobulin mutations are an important mechanism for HLA class I total loss, (phenotype No. I) and have been described in colon carcinomas, melanomas and lymphomas. We describe a new beta2 microglobulin mutation detected in the melanoma cell line GR-34. The new mutation reported here was identified as a deletion of 4 bases (TTCT) in the highly repetitive sequence CTCTCTCTTTCT located in the leader...
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