Article
Implication of the β2-microglobulin gene in the generation of tumor escape phenotypes.
Cancer immunology, immunotherapy : CII - 1 Sept 2012
Bernal Monica, Ruiz-Cabello Francisco, Concha Angel, Paschen Annette, Garrido Federico
Abstract excerpt
Classical MHC molecules present processed peptides from endogenous protein antigens on the cell surface, which allows CD8(+) cytotoxic T lymphocytes (CTLs) to recognize and respond to the abnormal antigen repertoire of hazardous cells, including tumor cells. The light chain, β2-microglobulin (β2m), is an essential constant component of all trimeric MHC class I molecules. There is convincing evidence that β2m...
Topics
- Colorectal Neoplasms
- Frameshift Mutation
- Histocompatibility Antigens Class I
- Humans
- Melanoma
- Microsatellite Instability
- Phenotype
- Tumor Escape
- beta 2-Microglobulin