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Article

Microsatellite instability analysis in tumors with different mechanisms for total loss of HLA expression.

Cancer immunology, immunotherapy : CII - 1 Mar 2000

Jimenez P, Cantón J, Concha A, Cabrera T, Fernández M, Real L M, García A, Serrano A, Garrido F, Ruiz-Cabello F

Abstract excerpt

Down-regulation of the expression of major histocompatibility complex molecules is a frequent event that is associated with the poor immunogenicity of tumor cells. Acquired resistance to T-cell-based immunotherapy has been associated with loss of functional beta2-microglobulin expression. This anomaly appears to be particularly relevant in tumors exhibiting a defect in DNA-mismatch repair, and induces structural...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Carcinoma, Squamous Cell

Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Share to Genes, MHC Class I

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Source

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Identifiers

PMID: 10752476
DOI: 10.1007/s002620050017
PMCID: PMC11037143

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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