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Article

Loss of HLA class-I alleles, heavy chains and beta 2-microglobulin in colorectal cancer.

International journal of cancer - 28 May 1992

Kaklamanis L, Gatter K C, Hill A B, Mortensen N, Harris A L, Krausa P, McMichael A, Bodmer J G, Bodmer W F

Abstract excerpt

Using immunohistochemical methods, we have analysed colorectal biopsies of normal mucosa, metaplastic polyps (5 cases), adenomas (15 cases) and adenocarcinomas (70 cases) with 13 monoclonal antibodies (MAbs) to allelic products of the HLA-A, B, C loci. Nine of the 70 carcinomas showed total loss of HLA Class-I molecules due to an underlying defect regarding not only the expression of beta 2-microglobulin (beta...

Topics

Alleles
Carcinoma
Colonic Polyps
Colorectal Neoplasms
HLA-A Antigens
HLA-B Antigens
HLA-C Antigens
Humans
Immunoglobulin Heavy Chains
beta 2-Microglobulin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1592528
DOI: 10.1002/ijc.2910510308

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1592528-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Loss of HLA class-I alleles, heavy chains and beta 2-microglobulin in colorectal cancer.PMID 1592528Read ↗

Mechanisms of loss of HLA class I expression on colorectal tumor cellsSemantic proximity Read ↗

High frequency of altered HLA class I phenotypes in invasive colorectal carcinomas.Semantic proximity Read ↗

Beta2-microglobulin gene mutation is not a common mechanism of HLA class I total loss in human tumors.Semantic proximity Read ↗

Total loss of MHC class I in colorectal tumors can be explained by two molecular pathways: β2‐microglobulin inactivation in MSI‐positive tumors and LMP7/TAP2 downregulation in MSI‐negative tumorsSemantic proximity Read ↗

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