High frequency of altered HLA class I phenotypes in laryngeal carcinomas.

doi:10.1016/s0198-8859(00)00097-5

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Article

High frequency of altered HLA class I phenotypes in laryngeal carcinomas.

Human immunology - 1 May 2000

Cabrera T, Salinero J, Fernandez M A, Garrido A, Esquivias J, Garrido F

Abstract excerpt

The exact frequency of HLA class I losses in human tumors is unknown. We have previously shown that primary breast and colorectal carcinomas frequently lose HLA class I molecules (88% and 73%, respectively). Now we report that this phenomenon is also a frequent event in laryngeal carcinomas. Of a total of 76 laryngeal carcinomas analyzed, 66% of the tumors showed an alteration in HLA class I phenotype. These...

Topics

Antibodies, Monoclonal
Antigens, Neoplasm
Carcinoma
HLA Antigens
HLA-A Antigens
HLA-B Antigens
HLA-C Antigens
Histocompatibility Antigens Class I
Histocompatibility Testing
Humans
Laryngeal Neoplasms
Loss of Heterozygosity
Mucous Membrane
Phenotype

Source

Open in PubMed

Identifiers

PMID: 10773352
DOI: 10.1016/s0198-8859(00)00097-5

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