Article
Tissue specific mutagenic and carcinogenic responses in NER defective mouse models.
Mutation research - 3 Jan 2007
Wijnhoven Susan W P, Hoogervorst Esther M, de Waard Harm, van der Horst Gijsbertus T J, van Steeg Harry
Abstract excerpt
Several mouse models with defects in genes encoding components of the nucleotide excision repair (NER) pathway have been developed. In NER two different sub-pathways are known, i.e. transcription-coupled repair (TC-NER) and global-genome repair (GG-NER). A defect in one particular NER protein can lead to a (partial) defect in GG-NER, TC-NER or both. GG-NER defects in mice predispose to cancer, both spontaneous as...
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