Article
Defective nucleotide excision repair in xpc mutant mice and its association with cancer predisposition.
Mutation research - 20 Mar 2000
Friedberg E C, Bond J P, Burns D K, Cheo D L, Greenblatt M S, Meira L B, Nahari D, Reis A M
Abstract excerpt
Mice that are genetically engineered are becoming increasingly more powerful tools for understanding the molecular pathology of many human hereditary diseases, especially those that confer an increased predisposition to cancer. We have generated mouse strains defective in the Xpc gene, which is required for nucleotide excision repair (NER) of DNA. Homozygous mutant mice are highly prone to skin cancer following...
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