Article
Characterization of defective nucleotide excision repair in XPC mutant mice.
Mutation research - 4 Mar 1997
Cheo D L, Ruven H J, Meira L B, Hammer R E, Burns D K, Tappe N J, van Zeeland A A, Mullenders L H, Friedberg E C
Abstract excerpt
Nucleotide excision repair (NER) is a fundamental process required for maintaining the integrity of the genome in cells exposed to environmental DNA damage. Humans defective in NER suffer from the hereditary cancer-prone disease xeroderma pigmentosum. In order to model this disease in mice a mutation in the mouse XPC gene was generated and used to replace a wild-type XPC allele in mouse embryonic stem cells by...
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