Article
DMBA-induced toxic and mutagenic responses vary dramatically between NER-deficient Xpa, Xpc and Csb mice.
Carcinogenesis - 1 Jul 2001
Wijnhoven S W, Kool H J, Mullenders L H, Slater R, van Zeeland A A, Vrieling H
Abstract excerpt
Heterogeneity in cancer susceptibility exists between patients with an inherited defect in nucleotide excision repair (NER). While xeroderma pigmentosum (XP) patients have elevated skin cancer rates, Cockayne syndrome (CS) patients do not appear to have increased cancer susceptibility. To investigate whether differences in mutagenesis are the basis for the variability in cancer proneness, we studied mutagenesis...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.