Article
A genome scan in families from Australia and New Zealand confirms the presence of a maternal susceptibility locus for pre-eclampsia, on chromosome 2.
American journal of human genetics - 1 Dec 2000
Moses E K, Lade J A, Guo G, Wilton A N, Grehan M, Freed K, Borg A, Terwilliger J D, North R, Cooper D W, Brennecke S P
Abstract excerpt
Epidemiological studies have shown that genetic factors contribute to the etiology of the common and serious pregnancy-specific disorder pre-eclampsia (PE)/eclampsia (E). Candidate-gene studies have provided evidence (albeit controversial) of linkage to several genes, including angiotensinogen on 1q42-43 and eNOS on 7q36. A recent medium-density genome scan in Icelandic families identified significant linkage to...
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