Article
Objective prioritization of positional candidate genes at a quantitative trait locus for pre-eclampsia on 2q22.
Molecular human reproduction - 1 Aug 2006
Moses E K, Fitzpatrick E, Freed K A, Dyer T D, Forrest S, Elliott K, Johnson M P, Blangero J, Brennecke S P
Abstract excerpt
Pre-eclampsia/eclampsia (PE/E) is a common, serious medical disorder of human pregnancy. Familial association of PE/E has been recognized for decades, but the genetics are complex and poorly understood. In an attempt to identify PE/E susceptibility genes, we embarked on a positional cloning strategy using 34 Australian and New Zealand PE/E pedigrees. An initial 10-cM resolution genome scan revealed a putative...
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