Article
Identification of two novel quantitative trait loci for pre-eclampsia susceptibility on chromosomes 5q and 13q using a variance components-based linkage approach.
Molecular human reproduction - 1 Jan 2007
Johnson M P, Fitzpatrick E, Dyer T D, Jowett J B M, Brennecke S P, Blangero J, Moses E K
Abstract excerpt
Pre-eclampsia/eclampsia (PE/E) is a common and serious disorder of human pregnancy that is associated with substantial maternal and perinatal morbidity and mortality. The suspected aetiology of PE/E is complex, with susceptibility being attributable to multiple environmental factors and a large genetic component. By assuming that the underlying liability towards PE/E susceptibility is inherently quantitative, any...
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