Article
Genetic dissection of the pre-eclampsia susceptibility locus on chromosome 2q22 reveals shared novel risk factors for cardiovascular disease.
Molecular human reproduction - 1 Jul 2013
Johnson Matthew P, Brennecke Shaun P, East Christine E, Dyer Thomas D, Roten Linda T, Proffitt J Michael, Melton Phillip E, Fenstad Mona H, Aalto-Viljakainen Tia, Mäkikallio Kaarin, Heinonen Seppo, Kajantie Eero, Kere Juha, Laivuori Hannele, Austgulen Rigmor, Blangero John, Moses Eric K
Abstract excerpt
Pre-eclampsia is an idiopathic pregnancy disorder promoting morbidity and mortality to both mother and child. Delivery of the fetus is the only means to resolve severe symptoms. Women with pre-eclamptic pregnancies demonstrate increased risk for later life cardiovascular disease (CVD) and good evidence suggests these two syndromes share several risk factors and pathophysiological mechanisms. To elucidate the...
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