Article
A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13.
Human molecular genetics - 1 Sept 1999
Arngrímsson R, Sigurõardóttir S, Frigge M L, Bjarnadóttir R I, Jónsson T, Stefánsson H, Baldursdóttir A, Einarsdóttir A S, Palsson B, Snorradóttir S, Lachmeijer A M, Nicolae D, Kong A, Bragason B T, Gulcher J R, Geirsson R T, Stefánsson K
Abstract excerpt
Pre-eclampsia is a common and serious disease and a major cause of maternal and infant mortality. Antenatal care systems world-wide screen for signs of the disease such as hypertension and proteinuria. Unlike most other human disorders it impacts two individuals, the mother and the child, both of whom can be severely affected. The pathophysiology of the disorder is incompletely understood, but familial clustering...
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