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Article

Clinical implications of microsatellite instability and MLH1 gene inactivation in sporadic insulinomas.

The Journal of clinical endocrinology and metabolism - 1 Sept 2009

Mei Mei, Deng Dajun, Liu Tong-Hua, Sang Xin-Ting, Lu Xin, Xiang Hong-Ding, Zhou Jing, Wu HaiYan, Yang YingMai, Chen Jie, Lu Chong-Mei, Chen Yuan-Jia

Abstract excerpt

CONTEXT: The molecular pathogenesis of sporadic insulinomas is unknown. There is a lack of biomarker to distinguish benign and malignant form of insulinoma. OBJECTIVE: Our objective was to confirm the occurrence of microsatellite instability (MSI) in insulinomas, to identify alterations of mismatch repair (MMR) genes in the tumors, and to evaluate the possibility to distinguish benign and malignant insulinoma or...

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Share to Adaptor Proteins, Signal Transducing
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Loss of Heterozygosity

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Share to MutL Protein Homolog 1

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Source

Identifiers

PMID: 19567531
DOI: 10.1210/jc.2009-0173

Genes

MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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