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Article

Alterations in the p16INK4a/CDKN2A tumor suppressor gene in gastrinomas.

The Journal of clinical endocrinology and metabolism - 1 Nov 2000

Serrano J, Goebel S U, Peghini P L, Lubensky I A, Gibril F, Jensen R T

Abstract excerpt

The p16INK4a/CDKN2A gene (p16INK4a) is frequently altered by homozygous deletion, mutation, or methylation in many nonendocrine tumors, and these alterations may be predictive of recurrence, tumor growth, or aggressiveness. Whether this is true of neuroendocrine tumors such as gastrinomas is uncl...

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Source

Identifiers

PMID: 11095446
DOI: 10.1210/jcem.85.11.6970

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11095446-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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