Article
CpG island methylation in carcinoid and pancreatic endocrine tumors.
Oncogene - 13 Feb 2003
Chan Annie On-On, Kim Sang Geol, Bedeir Ahmed, Issa Jean-Pierre, Hamilton Stanley R, Rashid Asif
Abstract excerpt
Carcinoid tumors and pancreatic endocrine tumors (PETs) are uncommon neuroendocrine neoplasms and their genetic alterations are not well characterized. CpG island methylation is a mechanism of gene silencing, and concordant methylation of multiple CpG islands as CpG island methylator phenotype (CIMP) has been described in tumors. The aim of this study was to evaluate CIMP in carcinoid tumors and PETs. We studied...
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