Article
Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas.
Cancer research - 1 Aug 1997
Schutte M, Hruban R H, Geradts J, Maynard R, Hilgers W, Rabindran S K, Moskaluk C A, Hahn S A, Schwarte-Waldhoff I, Schmiegel W, Baylin S B, Kern S E, Herman J G
Abstract excerpt
The Rb/p16 tumor-suppressive pathway is abrogated frequently in human tumors, either through inactivation of the Rb or p16INK4a/CDKN2/MTS1 tumor-suppressor proteins, or through alteration or overexpression of the cyclin D1 or cyclin-dependent kinase 4 oncoproteins. We reported previously that the p16 gene was genetically inactivated in 82% of pancreatic carcinomas. Nearly half of these inactivations were by...
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