Article
The C242T p22phox polymorphism and endothelium-dependent vasodilation in subjects with hypercholesterolaemia.
Clinical science (London, England : 1979) - 1 Jul 2003
Schneider Markus P, Hilgers Karl F, Huang Yale, Delles Christian, John Stefan, Oehmer Sebastian, Schmieder Roland E
Abstract excerpt
Oxidative stress plays a major pathogenetic role in cardiovascular disease. The C242T variant of the CYBA gene encoding the p22phox subunit of the NAD(P)H oxidase, a major source of superoxide production, has been shown to be associated with coronary artery disease and with vascular superoxide production in human veins ex vivo. Since superoxide degrades nitric oxide (NO), we hypothesized that the C242T variant...
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