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Article

C242T CYBA polymorphism of the NADPH oxidase is associated with reduced respiratory burst in human neutrophils.

Hypertension (Dallas, Tex. : 1979) - 1 Jun 2004

Wyche Keith E, Wang Shaoshan S, Griendling Kathy K, Dikalov Sergey I, Austin Harland, Rao Swapna, Fink Bruno, Harrison David G, Zafari A Maziar

Abstract excerpt

Oxidative stress contributes to the pathogenesis of atherosclerosis. p22phox-based NAD(P)H oxidases exist in the vessel wall, acting as important superoxide-generating systems in the vasculature. Some studies have identified reduced atherosclerosis in the presence of the C242T CYBA polymorphism, whereas others have not. Because vascular p22phox is identical to neutrophil p22phox, we studied the association...

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Source

Identifiers

PMID: 15078863
DOI: 10.1161/01.HYP.0000126579.50711.62

Genes

CYBA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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C242T CYBA polymorphism of the NADPH oxidase is associated with reduced respiratory burst in human neutrophils.PMID 15078863Read ↗

The C242T CYBA polymorphism as a major determinant of NADPH oxidase activity in patients with cardiovascular disease.Semantic proximity Read ↗

The C242T CYBA polymorphism of NADPH oxidase is associated with essential hypertension.Semantic proximity Read ↗

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NAD(P)H oxidase p22phox Gene C242T polymorphism and lipoprotein oxidation.Semantic proximity Read ↗

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