Article
The C242T CYBA polymorphism as a major determinant of NADPH oxidase activity in patients with cardiovascular disease.
Cardiovascular & hematological agents in medicinal chemistry - 1 Jul 2009
Mehranpour P, Wang S S, Blanco R R, Li W, Song Q, Lassègue B, Dikalov S I, Austin H, Zafari A M
Abstract excerpt
Single nucleotide polymorphisms (SNP) in the CYBA gene encoding p22(phox) have been associated with respiratory burst and cardiovascular phenotypes. We previously reported a reduced phagocytic respiratory burst activity in healthy adults with the C242T SNP, but found no correlation between CYBA SNPs and coronary artery disease (CAD) phenotype. Using lymphoblastoid cells, we hypothesized that CYBA SNPs affect...
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