Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The 242T variant of the CYBA gene polymorphism increases the risk of coronary artery disease associated with cigarette smoking and hypercholesterolemia.

Coronary artery disease - 1 Aug 2007

Niemiec Pawel, Zak Iwona, Wita Krystian

Abstract excerpt

OBJECTIVES: Hypercholesterolemia and cigarette smoking increase superoxide anion production, which is involved in many proatherosclerotic processes. NAD(P)H oxidases are the main source of superoxides in the vasculature, and the phagocyte oxidase (p22phox) encoded by the CYBA gene is a critical component of NAD(P)H oxidases. The 242T CYBA allele is associated with an increased low-density lipoprotein oxidation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholesterol
Share to Coronary Angiography

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Coronary Disease

Share to Follow-Up Studies

Share to Hypercholesterolemia

Share to NADPH Oxidases

Share to Regression Analysis

Share to Smoking

Source

Identifiers

PMID: 17627182
DOI: 10.1097/MCA.0b013e328241d97a

Genes

CAD
CYBA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The 242T variant of the CYBA gene polymorphism increases the risk of coronary artery disease associated with cigarette smoking and hypercholesterolemia.PMID 17627182Read ↗

The CYBA gene A640G polymorphism influences predispositions to coronary artery disease through interactions with cigarette smoking and hypercholesterolemia.Semantic proximity Read ↗

Insight into the role of CYBA A640G and C242T gene variants and coronary heart disease risk. A case-control study.Semantic proximity Read ↗

C242T polymorphism in CYBA gene (p22phox) and risk of coronary artery disease in a population of Caucasian Italians.Semantic proximity Read ↗

Functional effect of the C242T polymorphism in the NAD(P)H oxidase p22phox gene on vascular superoxide production in atherosclerosis.Semantic proximity Read ↗

The C242T CYBA polymorphism of NADPH oxidase is associated with essential hypertension.Semantic proximity Read ↗

CYBA gene variants as biomarkers for coronary artery disease.Semantic proximity Read ↗

The C242T p22phox polymorphism and endothelium-dependent vasodilation in subjects with hypercholesterolaemia.Semantic proximity Read ↗

Polymorphisms of C242T and A640G in CYBA gene and the risk of coronary artery disease: a meta-analysis.Semantic proximity Read ↗

The -930A>G polymorphism of the CYBA gene is associated with premature coronary artery disease. A case-control study and gene-risk factors interactions.Semantic proximity Read ↗

Effect of the CYBA C242T Polymorphism on Preeclampsia Pathogenesis in the Chinese Population.Semantic proximity Read ↗

Relationship of the p22phox (CYBA) gene polymorphism C242T with risk of coronary artery disease: a meta-analysis.Semantic proximity Read ↗

CYBA C242T polymorphism is a risk factor for pre-eclampsia:a case control studySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.