Article
Adenosine and its nucleotides activate wild-type and R117H CFTR through an A2B receptor-coupled pathway.
The American journal of physiology - 1 Feb 1999
Clancy J P, Ruiz F E, Sorscher E J
Abstract excerpt
ATP and its metabolites stimulate Cl- secretion in human epithelium in vitro and in vivo. The specific purinergic receptor subtypes that govern these effects have been difficult to separate, in part due to multiple parallel pathways for Cl- secretion in respiratory and intestinal epithelia. In a...
Topics
- Adenine Nucleotides
- Adenosine
- Animals
- Bronchi
- COS Cells
- Cell Line
- Chlorides
- Culture Techniques
- Cyclic AMP
- Cystic Fibrosis Transmembrane Conductance Regulator
- Epithelial Cells
- HeLa Cells
- Humans
- Mutation
- Phosphotransferases
- Receptors, Purinergic P1