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Article

CFTR: a hub for kinases and crosstalk of cAMP and Ca2+.

The FEBS journal - 1 Sept 2013

Kunzelmann Karl, Mehta Anil

Abstract excerpt

Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR). The resulting disease is pleiotropic consistent with the idea that CFTR acts as a node within a network of signalling proteins. CFTR is not only a regulator of multiple transport proteins and controlled by numerous kinases but also participates in many signalling pathways that are disrupted after expression of its...

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Identifiers

PMID: 23895508
DOI: 10.1111/febs.12457

Genes

CFTR

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