Article
Extracellular zinc and ATP restore chloride secretion across cystic fibrosis airway epithelia by triggering calcium entry.
The Journal of biological chemistry - 12 Mar 2004
Zsembery Akos, Fortenberry James A, Liang Lihua, Bebok Zsuzsa, Tucker Torry A, Boyce Amanda T, Braunstein Gavin M, Welty Elisabeth, Bell P Darwin, Sorscher Eric J, Clancy J P, Schwiebert Erik M
Abstract excerpt
Cystic fibrosis (CF) is caused by defective cyclic AMP-dependent cystic fibrosis transmembrane conductance regulator Cl(-) channels. Thus, CF epithelia fail to transport Cl(-) and water. A postulated therapeutic avenue in CF is activation of alternative Ca(2+)-dependent Cl(-) channels. We hypothesized that stimulation of Ca(2+) entry from the extracellular space could trigger a sustained Ca(2+) signal to activate...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.