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Article

CFTR and calcium-activated chloride channels in primary cultures of human airway gland cells of serous or mucous phenotype.

American journal of physiology. Lung cellular and molecular physiology - 1 Oct 2010

Fischer Horst, Illek Beate, Sachs Lorne, Finkbeiner Walter E, Widdicombe Jonathan H

Abstract excerpt

Using cell culture models, we have investigated the relative importance of cystic fibrosis transmembrane conductance regulator (CFTR) and calcium-activated chloride channels (CaCC) in Cl secretion by mucous and serous cells of human airway glands. In transepithelial recordings in Ussing chambers, the CFTR inhibitor CFTR(inh)-172 abolished 60% of baseline Cl secretion in serous cells and 70% in mucous. Flufenamic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20675434
DOI: 10.1152/ajplung.00421.2009
PMCID: PMC2957417

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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