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Article

Suppressors of mdm20 in yeast identify new alleles of ACT1 and TPM1 predicted to enhance actin-tropomyosin interactions.

Genetics - 1 Oct 2000

Singer J M, Hermann G J, Shaw J M

Abstract excerpt

The actin cytoskeleton is required for many aspects of cell division in yeast, including mitochondrial partitioning into growing buds (mitochondrial inheritance). Yeast cells lacking MDM20 function display defects in both mitochondrial inheritance and actin organization, specifically, a lack of visible actin cables and enhanced sensitivity to Latrunculin A. mdm20 mutants also exhibit a temperature-sensitive...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 11014803
DOI: 10.1093/genetics/156.2.523
PMCID: PMC1461267

Genes

TPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Suppressors of mdm20 in yeast identify new alleles of ACT1 and TPM1 predicted to enhance actin-tropomyosin interactions.PMID 11014803Read ↗

The yeast gene, MDM20, is necessary for mitochondrial inheritance and organization of the actin cytoskeleton.Semantic proximity Read ↗

Tropomyosin is essential in yeast, yet the TPM1 and TPM2 products perform distinct functions.Semantic proximity Read ↗

The rho-GAP encoded by BEM2 regulates cytoskeletal structure in budding yeast.Semantic proximity Read ↗

Mdm20 protein functions with Nat3 protein to acetylate Tpm1 protein and regulate tropomyosin-actin interactions in budding yeast.Semantic proximity Read ↗

Nat3p and Mdm20p are required for function of yeast NatB Nalpha-terminal acetyltransferase and of actin and tropomyosin.Semantic proximity Read ↗

The essential yeast Tcp1 protein affects actin and microtubules.Semantic proximity Read ↗

Overexpression of yeast homologs of the mammalian checkpoint gene RCC1 suppresses the class of alpha-tubulin mutations that arrest with excess microtubules.Semantic proximity Read ↗

Unexpected combinations of null mutations in genes encoding the actin cytoskeleton are lethal in yeast.Semantic proximity Read ↗

Site-directed mutagenesis of the yeast actin gene: a test for actin function in vivo.Semantic proximity Read ↗

Temperature-sensitive yeast mutants defective in mitochondrial inheritance.Semantic proximity Read ↗

Microtubule stability in budding yeast: characterization and dosage suppression of a benomyl-dependent tubulin mutant.Semantic proximity Read ↗

Identification of functional connections between calmodulin and the yeast actin cytoskeleton.Semantic proximity Read ↗

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