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Article

Tropomyosin is essential in yeast, yet the TPM1 and TPM2 products perform distinct functions.

The Journal of cell biology - 1 Feb 1995

Drees B, Brown C, Barrell B G, Bretscher A

Abstract excerpt

Sequence analysis of chromosome IX of Saccharomyces cerevisiae revealed an open reading frame of 166 residues, designated TPM2, having 64.5% sequence identity to TPM1, that encodes the major form of tropomyosin in yeast. Purification and characterization of Tpm2p revealed a protein with the characteristics of a bona fide tropomyosin; it is present in vivo at about one sixth the abundance of Tpm1p. Biochemical and...

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Source

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Identifiers

PMID: 7844152
DOI: 10.1083/jcb.128.3.383
PMCID: PMC2120352

Genes

TPM1
TPM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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