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Article

Tropomyosin is essential in yeast, yet the TPM1 and TPM2 products perform distinct functions.

The Journal of cell biology - 1 Feb 1995

Drees B, Brown C, Barrell B G, Bretscher A

Abstract excerpt

Sequence analysis of chromosome IX of Saccharomyces cerevisiae revealed an open reading frame of 166 residues, designated TPM2, having 64.5% sequence identity to TPM1, that encodes the major form of tropomyosin in yeast. Purification and characterization of Tpm2p revealed a protein with the characteristics of a bona fide tropomyosin; it is present in vivo at about one sixth the abundance of Tpm1p. Biochemical and...

Topics

Actins
Amino Acid Sequence
Haploidy
Molecular Sequence Data
Mutation
Protein Binding
Saccharomyces cerevisiae
Sequence Homology, Amino Acid
Tropomyosin

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Open in PubMed Open full text

Identifiers

PMID: 7844152
DOI: 10.1083/jcb.128.3.383
PMCID: PMC2120352

Genes

TPM1
TPM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7844152-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Tropomyosin is essential in yeast, yet the TPM1 and TPM2 products perform distinct functions.PMID 7844152Read ↗

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