Article
Identification of functional connections between calmodulin and the yeast actin cytoskeleton.
Genetics - 1 Sept 1998
Sekiya-Kawasaki M, Botstein D, Ohya Y
Abstract excerpt
One of four intragenic complementing groups of temperature-sensitive yeast calmodulin mutations, cmd1A, results in a characteristic functional defect in actin organization. We report here that among the complementing mutations, a representative cmd1A mutation (cmd1-226: F92A) is synthetically lethal with a mutation in MYO2 that encodes a class V unconventional myosin with calmodulin-binding domains. Gel overlay...
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