Article
Unexpected combinations of null mutations in genes encoding the actin cytoskeleton are lethal in yeast.
Molecular biology of the cell - 1 May 1993
Adams A E, Cooper J A, Drubin D G
Abstract excerpt
To understand the role of the actin cytoskeleton in cell physiology, and how actin-binding proteins regulate the actin cytoskeleton in vivo, we and others previously identified actin-binding proteins in Saccharomyces cerevisiae and studied the effect of null mutations in the genes for these proteins. A null mutation of the actin gene (ACT1) is lethal, but null mutations in the tropomyosin (TPM1), fimbrin (SAC6),...
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