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Article

The yeast gene, MDM20, is necessary for mitochondrial inheritance and organization of the actin cytoskeleton.

The Journal of cell biology - 7 Apr 1997

Hermann G J, King E J, Shaw J M

Abstract excerpt

In Saccharomyces cerevisiae, the growing bud inherits a portion of the mitochondrial network from the mother cell soon after it emerges. Although this polarized transport of mitochondria is thought to require functions of the cytoskeleton, there are conflicting reports concerning the nature of the cytoskeletal element involved. Here we report the isolation of a yeast mutant, mdm20, in which both mitochondrial...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 9105043
DOI: 10.1083/jcb.137.1.141
PMCID: PMC2139847

Genes

TPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The yeast gene, MDM20, is necessary for mitochondrial inheritance and organization of the actin cytoskeleton.PMID 9105043Read ↗

Suppressors of mdm20 in yeast identify new alleles of ACT1 and TPM1 predicted to enhance actin-tropomyosin interactions.Semantic proximity Read ↗

The rho-GAP encoded by BEM2 regulates cytoskeletal structure in budding yeast.Semantic proximity Read ↗

A protein complex containing Mdm10p, Mdm12p, and Mmm1p links mitochondrial membranes and DNA to the cytoskeleton-based segregation machinery.Semantic proximity Read ↗

The yeast dynamin-like protein, Mgm1p, functions on the mitochondrial outer membrane to mediate mitochondrial inheritance.Semantic proximity Read ↗

Regulation of mitochondrial morphology and inheritance by Mdm10p, a protein of the mitochondrial outer membrane.Semantic proximity Read ↗

Tropomyosin is essential in yeast, yet the TPM1 and TPM2 products perform distinct functions.Semantic proximity Read ↗

The myosin-related motor protein Myo2 is an essential mediator of bud-directed mitochondrial movement in yeast.Semantic proximity Read ↗

A role for unsaturated fatty acids in mitochondrial movement and inheritance.Semantic proximity Read ↗

Mutations altering the mitochondrial-cytoplasmic distribution of Mod5p implicate the actin cytoskeleton and mRNA 3' ends and/or protein synthesis in mitochondrial delivery.Semantic proximity Read ↗

Mdm12p, a component required for mitochondrial inheritance that is conserved between budding and fission yeast.Semantic proximity Read ↗

Mitochondrial distribution and inheritance.Semantic proximity Read ↗

Mutational analysis of Mdm1p function in nuclear and mitochondrial inheritance.Semantic proximity Read ↗

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