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Article

The rho-GAP encoded by BEM2 regulates cytoskeletal structure in budding yeast.

Molecular biology of the cell - 1 Aug 1995

Wang T, Bretscher A

Abstract excerpt

Microfilaments are required for polarized growth and morphogenesis in Saccharomyces cerevisiae. To accomplish this, actin cables and patches are redistributed during the cell cycle to direct secretory components to appropriate sites for cell growth. A major component of actin cables is tropomyosin I, encoded by TPM1, that determines or stabilizes these structures. Disruption of TPM1 is not lethal but results in...

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Source

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Identifiers

PMID: 7579704
DOI: 10.1091/mbc.6.8.1011
PMCID: PMC301259

Genes

TPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The rho-GAP encoded by BEM2 regulates cytoskeletal structure in budding yeast.PMID 7579704Read ↗

The yeast gene, MDM20, is necessary for mitochondrial inheritance and organization of the actin cytoskeleton.Semantic proximity Read ↗

Suppressors of mdm20 in yeast identify new alleles of ACT1 and TPM1 predicted to enhance actin-tropomyosin interactions.Semantic proximity Read ↗

Insight into actin organization and function in cytokinesis from analysis of fission yeast mutants.Semantic proximity Read ↗

Pheromone response in yeast: association of Bem1p with proteins of the MAP kinase cascade and actin.Semantic proximity Read ↗

Ras regulates the polarity of the yeast actin cytoskeleton through the stress response pathway.Semantic proximity Read ↗

Genetic interactions indicate a role for Mdg1p and the SH3 domain protein Bem1p in linking the G-protein mediated yeast pheromone signalling pathway to regulators of cell polarity.Semantic proximity Read ↗

Tropomyosin is essential in yeast, yet the TPM1 and TPM2 products perform distinct functions.Semantic proximity Read ↗

The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2.Semantic proximity Read ↗

Identification of novel, evolutionarily conserved Cdc42p-interacting proteins and of redundant pathways linking Cdc24p and Cdc42p to actin polarization in yeast.Semantic proximity Read ↗

Control of cellular morphogenesis by the Ip12/Bem2 GTPase-activating protein: possible role of protein phosphorylation.Semantic proximity Read ↗

Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton.Semantic proximity Read ↗

Rng2p, a protein required for cytokinesis in fission yeast, is a component of the actomyosin ring and the spindle pole body.Semantic proximity Read ↗

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