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Article

Somatic hypermutation and antigen-driven selection of B cells are altered in autoimmune diseases.

Journal of autoimmunity - 1 Dec 2010

Zuckerman Neta S, Hazanov Helena, Barak Michal, Edelman Hanna, Hess Shira, Shcolnik Hadas, Dunn-Walters Deborah, Mehr Ramit

Abstract excerpt

B cells have been found to play a critical role in the pathogenesis of several autoimmune (AI) diseases. A common feature amongst many AI diseases is the formation of ectopic germinal centers (GC) within the afflicted tissue or organ, in which activated B cells expand and undergo somatic hypermutation (SHM) and antigen-driven selection on their immunoglobulin variable region (IgV) genes. However, it is not yet...

Topics

Antibody Affinity
Autoantigens
Autoimmune Diseases
B-Lymphocytes
Cell Differentiation
Choristoma
Clonal Deletion
DNA Mutational Analysis
Germinal Center
Humans
Immunoglobulin Variable Region

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Organ Specificity

Somatic Hypermutation, Immunoglobulin

Source

Identifiers

PMID: 20727711
DOI: 10.1016/j.jaut.2010.07.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-20727711-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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